200 ml
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Chlorhexidine 200 ml

Skin and wound diseases
Indication

Prevention of sexually transmitted infections. Disinfection of purulent wounds, infected burn surfaces; treatment of infections of the skin and mucous membranes in surgery, obstetrics, gynecology, urology.

Features of application

It is necessary to avoid getting the drug into the wound of patients with an open craniocerebral injury, spinal cord injury, or perforation of the tympanic membrane. If the solution gets on the mucous membranes of the eye, they should be washed quickly and thoroughly with water.

Application method

Apply externally. In case of microtraumas, treat the skin around the wound with a solution, then apply a napkin soaked in the solution to the wound and fix it with a bandage or patch.

Duration of the course

The course of treatment is 10 days. Procedures are prescribed every other day.

Contraindication

Increased sensitivity to the components of the drug. Propensity to allergic reactions and allergic diseases, dermatitis, viral skin diseases.

The product is certified

Composition:

active substance: chlorhexidine digluconate;

100 ml of the drug contain a solution of chlorhexidine digluconate 20% — 0.25 ml;

excipient: purified water.

Medicinal form. Solution for external use.

Main physico-chemical properties: transparent, colorless, odorless liquid.

Pharmacotherapeutic group.

Antiseptic and disinfectants. ATX code D08A C02.

Pharmacological properties.

Pharmacodynamics.

Chlorhexidine digluconate is a cationic biguanide. Chlorhexidine has amino groups of cellular proteins. It penetrates the intracellular membranes of bacterial cells, settles on the cytoplasm and changes the function of the membrane, preventing oxygen consumption, which causes a decrease in the level of adenosine triphosphate and cell death. Destroys DNA and disrupts DNA synthesis in microorganisms. Provides long-term persistent antimicrobial activity, which prevents the reproduction of microorganisms for at least 6 hours after using the drug.

Chlorhexidine digluconate has a rapid and pronounced effect on gram-positive and gram-negative bacteria ( Treponema pallidum , Chlamydia spp., Ureaplasma spp ., Neisseria gonorrhoeae , Gardnerella vaginalis , Bacteroides fragilis ) , protozoa ( Trichomonas vaginalis ) , viruses ( Herpes viruses ) . In the presence of blood and other organic substances, the antimicrobial activity of chlorhexidine digluconate does not decrease.

Pharmacokinetics.

Does not penetrate intact skin. It is practically not absorbed from the gastrointestinal tract. After accidental ingestion of 300 mg, the maximum concentration is reached after 30 minutes and is 0.206 μg/l. It is excreted mostly with feces (90%), less than 1% is excreted by the kidneys.

Clinical characteristics.

Indication.

Prevention of sexually transmitted infections (syphilis, gonorrhea, trichomoniasis, chlamydia, ureaplasmosis, genital herpes).

Disinfection of purulent wounds, infected burn surfaces; treatment of infections of the skin and mucous membranes in surgery, obstetrics, gynecology, urology (urethritis, urethroprostatitis), dentistry (rinsing and irrigation – gingivitis, stomatitis, aphthae, periodontitis, alveolitis).

Contraindication.

Increased sensitivity to the components of the drug. Propensity to allergic reactions and allergic diseases, dermatitis, viral skin diseases. It is not recommended to use for treating the conjunctiva and washing cavities. It is also not recommended to use on wounds with a large surface, during operations in the areas of the central nervous system and auditory canal, in ophthalmology, for introduction into the auditory canal.

Interaction with other medicinal products and other types of interactions.

To avoid the development of dermatitis, it is not advisable to use chlorhexidine and iodine preparations at the same time.

Compatible with drugs containing a cationic group (benzalkonium chloride, cetrimonium bromide).

Ethanol enhances the effect of the drug.

Chlorhexidine digluconate is a cationic substance and is incompatible with soap and other anionic substances (colloids, gum arabic, carboxymethyl cellulose). At a concentration of 0.05%, chlorhexidine digluconate is incompatible with borates, carbonates, chlorides, citrates, phosphates, sulfates, as insoluble precipitates are formed.

Features of application.

It is necessary to avoid getting the drug into the wound of patients with an open craniocerebral injury, spinal cord injury, or perforation of the tympanic membrane. If the solution gets on the mucous membranes of the eye, they should be washed quickly and thoroughly with water.

Exposure of hypochlorite bleaching substances to fabrics previously in contact with preparations containing chlorhexidine can contribute to the appearance of brown spots on them.

The bactericidal effect of the drug increases with increasing temperature. At a temperature above 100 °C, the drug partially decomposes.

The drug is practically not absorbed in the stomach. In case of accidental ingestion of the product, the stomach should be washed using raw milk, raw egg, gelatin. If necessary, carry out symptomatic therapy.

Do not dilute with hard water. Can be sterilized in an autoclave at a temperature of 116 °C for 30 minutes. Do not sterilize with ionizing radiation.

You should not violate the rules of use of the medicinal product – it can harm your health.

Use during pregnancy or breastfeeding.

During pregnancy or breastfeeding, the drug should be used only when the expected benefit to the mother outweighs the potential risk to the fetus/child. Do not treat the surface of the mammary glands before feeding.

The ability to influence the speed of reaction when driving vehicles or other mechanisms.

Does not affect.

Method of application and dosage.

Apply externally. In case of microtraumas, treat the skin around the wound with a solution, then apply a napkin soaked in the solution to the wound and fix it with a bandage or patch.

For the prevention of sexually transmitted infections, the drug is effective if it is used no later than 2 hours after sexual intercourse. Before using the drug for the prevention of venereal diseases, you should empty your bladder, wash your hands and genitals. After that, treat the skin of the pubis, the inner surfaces of the thighs, and the genitals with a jet of solution. Using the nozzle, inject the contents of the bottle into the urethra: for men – 2-3 ml, for women – 1-2 ml (for women, inject 5-10 ml into the vagina and hold for 2-3 minutes). Treat the skin of the inner surfaces of the thighs, pubis, and genitals with the solution. After the procedure, you should not empty your bladder for 2 hours.

Complex treatment of urethritis and urethroprostatitis is carried out by injecting 2-3 ml of chlorhexidine digluconate solution into the urethra 1-2 times a day, the course of treatment is 10 days. Procedures are prescribed every other day.

Use the solution of the drug in the form of irrigations, rinses and applications – apply 5-10 ml of the solution to the affected surface of the skin or mucous membranes with exposure for 1-3 minutes 2-3 times a day (on a tampon or by irrigation).

During pregnancy or breastfeeding, the drug should be used in the usual recommended doses.

Children.

Do not use in children under 12 years of age.

Overdose.

Cases of overdose with external use are unknown.

Incorrect ingestion of a large amount of the substance (300 ml of chlorhexidine) leads to a fatal outcome with signs of liver and kidney failure.

When ingested, the drug is practically not absorbed – the stomach should be washed with milk, gelatin or raw egg.

If necessary, symptomatic therapy is carried out.

Adverse reactions.

In some cases, with increased individual sensitivity, hypersensitivity reactions, dryness and itching of the skin, dermatitis, stickiness of the skin of the hands, which is observed for 3-5 minutes, photosensitization are possible. In the treatment of gingivitis – staining of tooth enamel, tartar deposits, taste disturbances.

In the event of the appearance of any undesirable phenomena, you should stop using the drug and consult a doctor.

Expiration date.

3 years.

Do not use after the expiration date indicated on the package.

Storage conditions.

Store in the original packaging at a temperature not higher than 25 °C. Keep out of the reach of children.

Packaging.

100 ml in a bottle in a pack or without a pack or 200 ml in bottles.

Leave category.

Without a prescription.

Producer.

PrJSC Pharmaceutical factory “Viola”.

The location of the manufacturer and its address of the place of business.

Ukraine, 69063, m. Zaporozhye, Academician Amosova, 75.

Date last viewed. 02/24/2021

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