ANGILOR spray 50 ml

Description

Who ANGILORE is suitable for

A solution for local oral care when antiseptic treatment, reduction of inflammation, and pain relief are needed. Suitable for adults and children aged 6 and over for rinsing in cases of oral infections and for post-operative dental care.

When to choose ANGILORE

The product is used for local treatment of:

• oral infections;
• post-operative dental care.

What problem the product addresses

ANGILORE’s action is based on three active components and works comprehensively:

• Antiseptic action: hexetidine has antibacterial and antifungal effects against a broad spectrum of microorganisms.
• Anti-inflammatory support: choline salicylate helps reduce inflammation and discomfort.
• Pain relief: chlorobutanol provides an analgesic effect.
• Sustained action: the active substances bind to the mucous membrane and are gradually released.

Conditions and specifics of use

• Use as a local mouthwash solution.
• For a single rinse: dilute 10 ml or 2 teaspoons of the solution in ¼ glass of warm water.
• Rinse 2–4 times a day.
• Treatment course: 5 days.
• Do not swallow the product and avoid contact with the eyes.

Compatibility and comprehensive care

• Do not use together with products containing antiseptics.
• Hexetidine may be inactivated by alkaline solutions.
• Prolonged use is not recommended.
• If symptoms persist for more than 5 days and/or fever is present, the treatment approach should be reassessed.

Why choose ANGILORE

• Three benefits in one solution: antiseptic action, anti-inflammatory support, and pain relief.
• Convenient format: rinsing 2–4 times a day.
• Suitable for oral infections and post-operative dental care.
• Ukrainian manufacturer: PJSC Pharmaceutical Factory “Viola”.

Composition

Active substances: 100 ml of spray contain hexetidine in terms of 100% substance 0.1 g; choline salicylate in terms of 100% substance 0.5 g; chlorobutanol hemihydrate in terms of 100% anhydrous substance 0.25 g.

Excipients: sodium saccharin, polysorbate 20, sorbic acid, ethanol 96%, eucalyptol, methyl salicylate, lime oil, sage oil, glycerin, purified water.

Dosage form: oral spray.

Main physicochemical properties: a transparent, slightly colored solution with a specific aromatic smell.

Pharmacotherapeutic group

Medical products used in treatment of the throats` diseases. Antiseptics. ATX code R02A A20.

Pharmacological properties

Pharmacodynamics.

The action of the drug is determined by three active components.

Antibacterial and antifungal activity: hexetidine has an antibacterial effect on both gram-positive and gram-negative strains of microorganisms, both aerobes and anaerobes. Hexetidine generally has a bacteriostatic effect on aerobic strains, while the bactericidal effect is weak. On anaerobic strains, hexetidine has a pronounced bactericidal effect. The mechanism of action consists in a competitive action with thiamine: the structure of hexetidine is similar to the structure of thiamine, necessary for the growth of microorganisms.

Anti-inflammatory activity: choline salicylate has an analgesic, antipyretic and anti-inflammatory effect; to be used for the treatment of diseases of the oral cavity.

Analgesic activity: chlorobutanol has an analgesic effect. It can be used, in particular, in otolaryngology (drops in the nose, rinsing) and in dental practice (applications and irrigation). Classically, it can be used as an anesthetic.

Active substances are fixed on the mucous membrane of the oral cavity, from where they are gradually released.

Clinical characteristics

Indications

Antibacterial and analgesic agent for local treatment of diseases of the mucous membrane of the oral cavity and oropharynx.

Contraindications

• Hypersensitivity to any component of the drug;
• atrophic pharyngitis;
• bronchial asthma or any other diseases of the respiratory tract associated with existing increased sensitivity of the respiratory tract.

Interaction with other medicinal products and other types of interactions

Do not use together with preparations containing antiseptics. Hexetidine can be inactivated by alkaline solutions.

Features of application

When you use the drug, do not swallow and avoid contact with the eyes, as it contains ethanol. The drug should be used with caution in patients with epilepsy (may reduce the epileptic threshold and cause seizures in children), and in patients with a tendency to allergic reactions, including bronchial asthma (especially in patients with an allergy to acetylsalicylic acid).

If signs of hypersensitivity to the drug appear, its use should be immediately stop. Since the drug contains ethanol, it should be prescribed with caution to patients with liver diseases.

Long-term use is not recommended, as the natural microbial balance of the oral cavity and throat may change, where there is a risk of bacterial and fungal dissemination. If general clinical signs of bacterial infection appear, general antibacterial therapy should be prescribed.

If symptoms persist longer than 5 days and/or elevated body temperature, it is necessary to review treatment tactics. In case of exacerbation of inflammation, treatment with the drug should be discontinued.

Using during pregnancy or breastfeeding.

Data from studies in humans on the possibility of penetration through the placenta and excretion of hexetidine in breast milk are absent, so the drug should not be used during pregnancy or breastfeeding.

The ability to influence the speed of reaction when driving a motor vehicle or other mechanisms.

The drug contains ethanol. Drivers are not advised to drive for 30 minutes after using the drug.

Method of application and dosage

Use as a local agent for irrigation of the oral cavity and oropharynx.

Adults and children over 15 years of age: 1 spray 4-6 times a day.

Children aged 6 to 15 years: 1 spray 2-3 times a day.

The course of treatment is no longer than 5 days.

Children.

Do not use in children under 6 years of age.

Overdose

There were no reports of drug overdose. Due to the absorption of a sufficient amount of the solution in the oral cavity, alcohol intoxication may occur due to the content of ethyl alcohol. The concentration of hexetidine in the drug is not toxic if the drug is used as intended.

The occurrence of acute alcohol intoxication is unlikely. If a child swallows a significant dose of the drug, alcohol intoxication may occur due to the ethyl alcohol content.

There were no cases of excessive use of hexetidine, which led to hypersensitivity reactions.

Overdose treatment is symptomatic but rarely necessary. If a child swallows the contents of the vial, consult a doctor immediately. It is necessary to consider gastric lavage within 2 hours after ingestion and take measures to eliminate signs of alcohol intoxication.

Adverse reactions

From the side of the immune system: hypersensitivity reactions, including urticaria, angioedema, laryngospasm, bronchospasm.

From the side of the nervous system: ageusia, dysgeusia, change in taste sensations within 48 hours (the feeling of sweet can change twice to the feeling of bitter).

From the respiratory system, organs of the chest and mediastinum: cough, shortness of breath.

From the side of the digestive system: dry mouth, dysphagia, increased salivary glands, pain when swallowing. In case of accidental ingestion of the drug, gastrointestinal disorders may occur, primarily nausea and vomiting.

From the side of the skin and subcutaneous tissue: allergic contact dermatitis, skin reactions (rash).

General disorders and condition of the site of application: local reactions (reversible color change of teeth and tongue); sensitivity of the mucous membrane (burning, feeling of numbness); irritation (soreness, feeling of heat, itching) of the tongue and/or mucous membrane of the oral cavity; decreased sensitivity; paresthesia of the mucous membrane; inflammation; blisters; occurrence of ulcers on the mucous membrane, a feeling of itching in the throat, swelling at the point of contact, dryness of the mucous membrane of the nose/throat.

Expiration date: 2 years.

Storage conditions: store in the original packaging at a temperature not higher than 25 °C. Keep out of the reach of children.

Packaging: 50 ml in a glass bottle, 1 bottle with a sprayer in a pack.

Leave category: without a prescription.

Manufacturer: PrJSC Pharmaceutical factory “Viola”.

Location of the manufacturer and the address of the place of its activity: Ukraine, 69063, m. Zaporozhye, Akademika Amosova, 75.