Metroviol Denta 20 g

Description

The combined drug has a pronounced antimicrobial and anti-inflammatory effect

Who Metroviol Denta is suitable for

A gum gel for local use in dentistry. Suitable for adults with infectious and inflammatory diseases of the periodontium and oral mucosa, as well as for preventing exacerbations of chronic gingivitis and periodontitis after consultation with a dentist.

When to choose Metroviol Denta

The medicine is used to treat:

• catarrhal hypertrophic gingivitis, acute and chronic course;
• acute ulcerative-necrotic gingivitis;
• generalized periodontitis, chronic and exacerbated course;
• injuries of the oral mucosa caused by dental prostheses;
• alveolitis after tooth extraction.

The gel is also used to prevent exacerbations of chronic gingivitis and periodontitis.

What problem the medicine solves

Metroviol Denta combines two active substances — metronidazole and chlorhexidine — so it works comprehensively:

• Metronidazole has antiprotozoal and antibacterial action and is active against anaerobic bacteria associated with periodontal diseases.
• Chlorhexidine acts as a bactericidal antiseptic and is active against a wide range of microorganisms.
• Local application to the gums ensures a high concentration of metronidazole in the application area.
• The gel helps in the complex treatment of inflammation of the gums, periodontium, and oral mucosa.

Conditions and features of use

• Use locally, only for dental use.
• The medicine should be used after consultation with a dentist.
• For gingivitis, adults should apply the gel to the gums by finger massage or with a cotton swab 2 times a day.
• After applying the gel, do not rinse the mouth, drink, or eat for 30 minutes.
• The average duration of treatment is 7–10 days.
• For periodontitis, after removal of dental deposits, the gel is applied to the gums and periodontal pockets are treated; the application duration is 30 minutes.
• To prevent exacerbations of chronic gingivitis and periodontitis, courses are carried out 2–3 times a year.
• Use of the gel does not replace hygienic tooth brushing.

Compatibility and comprehensive care

• When used locally in recommended doses, no systemic interaction with other medicines has been identified, but caution is required when combined with certain medicines.
• Metronidazole may enhance the effect of warfarin and other coumarin anticoagulants.
• The medicine should not be combined with disulfiram due to the risk of neurological and psychotic reactions.
• Alcohol must not be consumed during use.
• Long-term use may cause brown discoloration of the teeth and tongue and temporary changes in taste.
• If symptoms do not disappear, worsen, or new symptoms appear, use should be stopped and a doctor should be consulted.

Why choose Metroviol Denta

• A combined dental gel with metronidazole and chlorhexidine.
• Suitable for the complex treatment of infectious and inflammatory diseases of the gums, periodontium, and oral mucosa.
• May be used to prevent exacerbations of chronic gingivitis and periodontitis.
• Convenient format for application to the gums using finger massage or a cotton swab.
• Ukrainian manufacturer: PJSC “Pharmaceutical Factory “Viola”.

The gel for the treatment of diseases of the oral cavity is highly effective, as it contains active components – metronidazole and chlorhexidine.
They destroy pathogenic microorganisms, reduce swelling and redness, eliminate discomfort.

If you suffer from gingivitis in acute or chronic form, periodontitis, alveolitis (inflammation of the socket after tooth extraction) or have mucosal injuries caused by dentures, try Metroviol Denta.
Due to the combined composition, the gel has a bactericidal effect against anaerobic and aerobic bacteria. Effectively relieves inflammation.

Metroviol Denta / Metroviol denta – can be used to prevent the exacerbation of chronic gum diseases.

Application: apply a thin layer of the gel to the inflamed gums with your fingers or a cotton swab 2 times a day. In addition, the affected tissues should be massaged. After applying the drug, you cannot drink, eat or rinse your mouth for half an hour.

Composition:
active substances: metronidazole benzoate, chlorhexidine gluconate;
1 g of gel contains metronidazole benzoate in terms of metronidazole – 10 mg, chlorhexidine gluconate solution 20% in terms of chlorhexidine digluconate – 0.5 mg;
auxiliary substances: carbomer, propylene glycol, sodium saccharin, disodium edetate (Trilon B), trometamol, lemon oil, purified water.

Medicinal form. Gum gel.
The main physical and chemical properties: a white or almost white gel with a specific smell.

Pharmacotherapeutic group. Antimicrobial and antiseptic preparations for local use in dentistry. Code ATX A01A V.

Pharmacological properties.
Pharmacodynamics.
Combined antimicrobial drug for the complex treatment and prevention of some infectious and inflammatory diseases of the oral cavity.
The effectiveness of the drug is due to the presence of two antibacterial components – metronidazole and chlorhexidine.
Metronidazole is a derivative of nitroimidazole, which has antiprozoic and antibacterial effects. Active against anaerobic bacteria that cause periodontal diseases: Porphyromonas gingivalis, Prevotella intermedia, Prevotella denticola, Fusobacterium fusiformis, Wolinella recta, Eikenella corrodens, Borrelia vincenti, Bacteroides melaninogenicus, Selenomonas spp.
Chlorhexidine is an antiseptic with bactericidal action. Its action consists in increasing the permeability of bacterial cell walls, as a result of which chlorhexidine penetrates into the bacterial cytoplasm, which leads to the death of cells. Active against a wide range of vegetative forms of gram-negative (Treponema spp., Neisseria gonorrheae, Trichomonas spp., Chalmydia spp., Ureaplasma spp., Bacteroides fragilis) and gram-positive microorganisms, as well as yeast, dermatophytes and lipophilic viruses.
Some strains of Pseudomonas spp. and Proteus spp. have a low sensitivity to chlorhexidine, while acid-resistant bacteria and bacterial spores are not susceptible to the action of this substance. Chlorhexidine does not impair the functional activity of lactobacilli.
Pharmacokinetics.
The minimum inhibitory concentration (MIC50) of metronidazole for anaerobic bacteria is below 1 μg/ml. With local application of the drug (applying to the gums), the concentration of metronidazole in the gum area is significantly higher than with oral administration of the drug, and the level of systemic absorption of metronidazole with local application is significantly lower than with oral administration. The drug is well absorbed from the gastrointestinal tract and can be detected at an inhibitory level for bacteria in blood and saliva within 1 hour after administration. Metabolism of metronidazole mainly occurs in the liver. The main route of elimination of metronidazole and its metabolites is the kidneys. Reduced renal function does not alter the pharmacokinetics of a single dose of metronidazole.
In case of ingestion of an excess of chlorhexidine during its local application as part of a dental gel, approximately 1% of the dose that entered the stomach is absorbed from the digestive tract. Chlorhexidine does not accumulate in the body and is minimally metabolized.

Clinical characteristics.
Indication.
For the treatment of infectious and inflammatory diseases of the periodontium and oral mucosa:
• catarrhal hypertrophic gingivitis, acute and chronic course;
• acute ulcerative-necrotic gingivitis (Vincent’s gingivitis);
• generalized periodontitis, chronic and acute course;
• trauma to the mucous membrane of the oral cavity caused by dentures;
• alveolitis (inflammation of the socket after tooth extraction)
For the prevention of exacerbations of chronic gingivitis and periodontitis.

Contraindication.
Hypersensitivity to metronidazole, chlorhexidine, as well as nitroimidazole derivatives and any components included in the medicinal product.
Contraindicated in patients with confirmed blood dyscrasia or a history of blood dyscrasia.
Contraindicated in patients with diseases of the peripheral and central nervous system.

Special security measures.
Avoid getting the gel in the eyes.

Interaction with other medicinal products and other types of interactions.
When applied topically in recommended doses, no systemic interaction of Metroviol Denta gel with other medicinal products was detected. However, caution should be exercised when prescribing Metroviol Denta gel with certain medications.
Warfarin and other coumarin anticoagulants. Metronidazole increases the anticoagulant effect, which leads to a prolongation of the time of prothrombin formation.
Disulfiram. Simultaneous use increases the toxicity of drugs, which can lead to the development of neurological symptoms.
Phenobarbital, phenytin, anticonvulsants based on hydantoin. When used simultaneously with metronidazole, the antimicrobial activity of the latter decreases. The reason is the accelerated metabolism of metronidazole.
Cimetidine. Suppresses the metabolism of metronidazole, which can cause an increase in the concentration of metronidazole in blood serum.
Alcohol. Metronidazole causes alcohol intolerance. Simultaneous use of alcohol and metronidazole can cause symptoms of toxic psychosis, nausea, hypotension, tachycardia, diaphoresis or shortness of breath, and in some cases severe hypotension and shock may occur. These reactions usually occur within 24 hours, but can occur up to 2 weeks after drinking alcohol.

Features of application.
The use of Metroviol Denta is not a substitute for hygienic tooth brushing.
Alcohol should not be consumed while using the drug, as it can cause stomach cramps, nausea, vomiting, headache, and facial flushing.
Metronidazole should not be used concurrently with disulfiram, as it may cause psychotic reactions and confusion.
Long-term use can cause brown discoloration of the teeth and tongue.
The use of Metroviol Denta gel can cause temporary changes in taste sensations.
Use during pregnancy or breastfeeding.
The drug should not be used during pregnancy.
During the period of treatment with the drug, breastfeeding should be stopped.
The ability to influence the speed of reaction when driving vehicles or other mechanisms.
The use of the drug in the specified dose does not affect the driving of vehicles or potentially dangerous mechanisms.

Method of application and dosage.
Topical, for dental use only!
Use the drug after consultation with a dentist.
For adults with inflammation of the gums (gingivitis), Metroviol Denta gel should be applied to the gums with the help of finger massage or a cotton swab 2 times a day. After applying the gel, do not rinse your mouth, drink or eat for 30 minutes. The average duration of treatment is 7–10 days.
In case of periodontitis: after removing dental deposits, periodontal pockets should be treated with Metroviol Denta gel, and the gel should also be applied to the gums. The duration of the application is 30 minutes. The number of procedures depends on the severity of the disease. In the future, the patient applies the gel independently. Metroviol Denta should be applied to the gum area 2 times a day for 7–10 days.
To prevent exacerbations of chronic gingivitis and periodontitis, Metroviol Denta gel is applied to the gums 2 times a day for 7–10 days. Preventive treatment courses should be carried out 2-3 times a year.
For the treatment of post-extraction alveolitis, treat the hole with Metroviol Denta gel after tooth extraction, then the patient applies the gel independently 2-3 times a day for 7-10 days.
To prevent exacerbation of chronic gingivitis and periodontitis, Metroviol Denta gel should be applied 2 times a day to the affected areas for 7-10 days. Conduct preventive courses 2-3 times a year.
For the prevention of exacerbations of chronic gingivitis and periodontitis, with bleeding gums and bad breath in the evening after hygienic tooth brushing, Metro-viol Dent gel should be rubbed into the gum area for 2-3 minutes with the help of finger massage or a cotton swab, after rubbing, spit out, do not close your mouth rinse.
In order to prevent exacerbations in patients with catarrhal gingivitis and mild generalized periodontitis, in the morning and in the evening, after hygienic brushing of the teeth, with the help of finger massage or a cotton swab, Metroviol Denta gel should be rubbed for 2-3 minutes, after the procedure, refrain from rinsing the mouth and fluid intake within one hour. Preventive treatment courses lasting 2 weeks should be carried out 2-3 times a year.
Children .
It is not recommended to prescribe the drug to children under 18 years of age.

Overdose .
There are no known cases of Metroviol Denta gel overdose with local application.
Accidental or intentional ingestion of a large amount of gel can lead to exacerbation of adverse reactions that were initially caused by metronidazole (chlorhexidine is practically not absorbed from the gastrointestinal tract). These reactions include nausea, vomiting, dizziness. In more serious cases, paresthesia and convulsions may occur. High doses and long-term systemic treatment with metronidazole are associated with the development of leukopenia, neutropenia, increased risk of peripheral neuropathy and toxicity of the central nervous system. To treat an overdose, it is necessary to wash the stomach and, if necessary, carry out symptomatic therapy.

Adverse reactions.
With local application of Metroviol Denta gel, the risk of developing systemic side effects is insignificant, but sometimes the reactions described below can be observed.
From the side of the immune system: allergic reactions, including skin rash, itching, urticaria, angioedema, anaphylaxis, including anaphylactic shock. One case of eyelid edema was described as a manifestation of an angioneurotic reaction.
From the side of the nervous system: headache.
On the part of the organs of vision: when the gel gets on the area close to the eyes, lacrimation, dryness of the mucous membrane and short-term redness may appear.
From the gastrointestinal tract: metallic taste in the mouth, bitter taste in the mouth, nausea, possible appearance of plaques in the oral cavity, on the surface of the teeth and tongue.
Reactions at the site of application: burning at the site of application, irritation at the site of application.
Data from post-marketing studies.
With oral use of chlorhexidine, hypersensitivity may occur, including symptoms of anaphylaxis, mouth irritation, discoloration of teeth and tongue, increased tartar formation, change in taste sensations, bitter taste in the mouth, as well as burning, numbness, dryness and soreness of the oral mucosa.
In post-marketing use, urticaria with swelling of the face, lips, mouth, throat and itching, difficulty breathing, hoarseness, fainting, and allergic reactions (anaphylaxis) in the oral cavity on open wounds have been reported.
If these or other unwanted effects appear, you should stop treatment and consult a doctor.

Expiration date. 3 years.
Do not use the drug after the expiration date indicated on the package.

Storage conditions. Store in the original packaging at a temperature not higher than 25 °C. Keep out of the reach of children.
Packaging. 20 g in tubes in a pack or without a pack.

Leave category. Without a prescription.

Producer. PrJSC Pharmaceutical factory “Viola”.

The location of the manufacturer and its address of the place of business.
Ukraine, 69063, m. Zaporozhye, Akademika Amosova, 75.